Hepatic iron in dialysed patients given intravenous iron dextran.

The Treatment of Iron-deficiency Anemia with Intravenous Iron Dextran.

I N THE THERAPY of iron-deficiency anemia, iron given orally is safe, effective, inexpensive, and is usually the treatment of choice, but occasionally when a rapid replenishment of iron stores is desired, administration by the parenteral route is indicated. Heath, Strauss and Castle,1 in 1938, showed that when 16-32 mg. of iron as ferric ammonium citrate is injected subcutaneously or intramuscu...

Intravenous iron-dextran: studies on unsaturated iron-binding capacity.

A method is described for measuring the plasma unsaturated iron-binding capacity in the presence of very high concentrations of iron as iron-dextran. The procedure utilizes (59)Fe to label the apotransferrin with subsequent separation of ionic iron from transferrin-bound iron on an ion exchange or Sephadex G.25 column. The unsaturated iron-binding capacity has been measured in rabbits and dogs ...

Precautions in the intravenous use of iron-dextran.

Intravenous iron dextran for severe refractory restless legs syndrome.

Reduced brain iron is strongly associated with restless legs syndrome (RLS). Oral iron supplements are commonly recommended for RLS but are largely ineffective due to poor absorption and poor tolerability at required doses. Intravenous iron dextran has been shown to increase brain iron content. Surprisingly only a few reports have ever presented data on the clinical effect of high dose intraven...

Effect of intravenous iron dextran on rheumatoid synovitis.

Eleven patients with rheumatoid arthritis received a total dose infusion of iron dextran for anaemia. Two of them had anaphylactic reactions and the remaining nine an exacerbation of synovitis. Quantitative infrared thermal imaging was used to assess the extent and distribution of joint involvement resulting from this therapy. In all eight patients examined the 'thermographic index' increased i...